CAS 61574-54-7|Pregnenolone-d4-1
Introduction：Basic information about CAS 61574-54-7|Pregnenolone-d4-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pregnenolone-d4-1 | ||
|---|---|---|---|
| CAS Number | 61574-54-7 | Molecular Weight | 320.50200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C21H28D4O2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | pregnenolone-17alpha,21,21,21-d4 |
|---|---|
| Synonym | More Synonyms |
Pregnenolone-d4-1 BiologicalActivity
| Description | Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [3]. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. [4]. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7. |
Chemical & Physical Properties
| Molecular Formula | C21H28D4O2 |
|---|---|
| Molecular Weight | 320.50200 |
| Exact Mass | 320.26500 |
| PSA | 37.30000 |
| LogP | 4.51530 |
| InChIKey | ORNBQBCIOKFOEO-QVFJSNPXSA-N |
| SMILES | CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
Synonyms
| 1,2:4,5-di-O-cyclohexylidene inositol |
| 1,2:4,5-Biscyclohexylidene DL-myo-Inositol |
| 1,2:4,5-Di-O-cyclohexylidene-D,L-myo-inositol |
| 1,2:4,5-dicyclohexylidene-myo-inositol |
| 1,2:4,5-di-O,O-cyclohexylidene-myo-inositol |
| 17,21,21,21-d4-pregnenolone |
