Introduction：Basic information about CAS 1242137-15-0|Enzalutamide carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Enzalutamide carboxylic acid |
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| CAS Number | 1242137-15-0 | Molecular Weight | 451.39400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H13F4N3O3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Enzalutamide Carboxylic acid |
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| Synonym | More Synonyms |
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Enzalutamide carboxylic acid BiologicalActivity
| Description | Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vitro | Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1]. |
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| References | [1]. van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145. |
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Chemical & Physical Properties
| Molecular Formula | C20H13F4N3O3S |
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| Molecular Weight | 451.39400 |
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| Exact Mass | 451.06100 |
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| PSA | 116.73000 |
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| LogP | 4.46108 |
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Safety Information
Synonyms
