CAS 7665-72-7|tert-butyl glycidyl ether

Introduction：Basic information about CAS 7665-72-7|tert-butyl glycidyl ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles2
7. Synonyms

Common Name	tert-butyl glycidyl ether
CAS Number	7665-72-7	Molecular Weight	130.18500
Density	0.917 g/mL at 25 °C(lit.)	Boiling Point	150-152 °C
Molecular Formula	C₇H₁₄O₂	Melting Point	-70°C
MSDS	ChineseUSA	Flash Point	55°C
Symbol	GHS02, GHS07	Signal Word	Warning

Names

Name	1-Tert-Butoxy-2,3-Epoxypropane
Synonym	More Synonyms

Chemical & Physical Properties

Density	0.917 g/mL at 25 °C(lit.)
Boiling Point	150-152 °C
Melting Point	-70°C
Molecular Formula	C₇H₁₄O₂
Molecular Weight	130.18500
Flash Point	55°C
Exact Mass	130.09900
PSA	21.76000
LogP	1.20030
Index of Refraction	n20/D 1.417(lit.)
InChIKey	SFJRUJUEMVAZLM-UHFFFAOYSA-N
SMILES	CC(C)(C)OCC1CO1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR0475000

CHEMICAL NAME :: Oxirane, ((1,1-dimethylethoxy)methyl)-

CAS REGISTRY NUMBER :: 7665-72-7

BEILSTEIN REFERENCE NO. :: 0103483

LAST UPDATED :: 199806

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H14-O2

MOLECULAR WEIGHT :: 130.21

WISWESSER LINE NOTATION :: T3OTJ B1OX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/2W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 ppm/6H/2W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1000 ppm/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1250 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Skin;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5364 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 154 (estimated) No. of Female Employees: 3 (estimated)

Safety Information

Symbol	GHS02, GHS07
Signal Word	Warning
Hazard Statements	H226-H302-H317-H319
Supplemental HS	May form explosive peroxides.
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn
Risk Phrases	10-19-22-36-43
Safety Phrases	S16-S26-S36/37
RIDADR	UN 3271 3/PG 3
WGK Germany	3
RTECS	RR0475000
Packaging Group	III
Hazard Class	3.2
HS Code	2910900090

Customs

HS Code	2910900090
Summary	2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles2

Unscheduled DNA synthesis induced in human lymphocytes by butyl glycidyl ethers.

Mutat. Res. 102(2) , 193-200, (1982)

Unscheduled DNA synthesis (UDS) was examined in normal human peripheral blood lymphocytes (HPBL) exposed to n- and tert.-butyl glycidyl ethers (BGE). n-BGE, which is currently used as a major reactive...

Purification and characterisation of a novel enantioselective epoxide hydrolase from Aspergillus niger M200.

Biochim. Biophys. Acta 1760(2) , 245-252, (2006)

Purification of a novel enantioselective epoxide hydrolase from Aspergillus niger M200 has been achieved using ammonium sulphate precipitation, ionic exchange, hydrophobic interaction, and size-exclus...

Synonyms

MFCD00010050

EINECS 231-640-0

tert-butyl glycidyl ether

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