Introduction：Basic information about CAS 325457-99-6|ICA 110381, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ICA 110381 |
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| CAS Number | 325457-99-6 | Molecular Weight | 267.11 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C12H8Cl2N2O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide |
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| Synonym | More Synonyms |
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ICA 110381 BiologicalActivity
| Description | ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1] |
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| References | [1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. |
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Chemical & Physical Properties
| Molecular Formula | C12H8Cl2N2O |
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| Molecular Weight | 267.11 |
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| Exact Mass | 266.00100 |
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| PSA | 41.99000 |
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| LogP | 3.71370 |
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| InChIKey | FOYOGIUAMYSVIT-UHFFFAOYSA-N |
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| SMILES | O=C(Nc1ccc(Cl)nc1)c1ccc(Cl)cc1 |
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Synonyms
| 2-acetamido-6-chloropyridine |
